グリア細胞由来神経栄養因子（GDNF）ファミリーと痛み

Glial cell line–derived neurotrophic factor (GDNF) family ligand (GFL) consists of GDNF, neurturin (NRTN), artemin (ARTN), and persephin (PSPN). These GFLs signal through a receptor complex consisting coreceptor (GFRα1–4) as binding component, which has no intracellular domain is anchored to the plasma membrane with glycosylphosphatidylinositol, transmembrane RET (rearranged during transfection) tyrosine kinase signaling component. GFRαs define specificity: GDNF binds GFRα1, NRTN GFRα2, ARTN GFRα3, PSPN GFRα4 high affinity. Small dorsal root ganglion (DRG) neurons have been classified property plant lectin IB4, majority IB4–binding DRG express RET. In rats about 80% nociceptive either or both.